A new study points to a “bone switch” (GPR133): turning it on with a compound called AP503 made mouse bones stronger and even reversed osteoporosis-like loss. Early, preclinical—but it hints at treatments that rebuild bone, not just slow decline.
Russia says it’ll launch a **personalized mRNA cancer vaccine** in 2025—potentially free to patients. Intriguing, but it’s still light on peer-reviewed human data, so file under **watch-list**, not proven therapy. ([drvaccines.com][1])
[1]: https://www.drvaccines.com/blog/russias-new-mrna-cancer-vaccine-launching-in-2025-a-breakthrough-in-cancer-treatment?utm_source=chatgpt.com “Russia’s New mRNA Cancer Vaccine Launching in 2025”
A “four-in-one” obesity drug that targets GLP-1, GIP, glucagon, and PYY aims to push weight loss toward \~30% while reducing nausea and muscle loss; it’s still preclinical (no human data yet), but it points beyond today’s GLP-1s. ([Yahoo][1])
[1]: https://www.yahoo.com/news/articles/next-ozempic-aims-deliver-30-110036301.html?utm_source=chatgpt.com “‘Next Ozempic’ aims to deliver 30% weight loss with fewer side …”
Exact Sciences’ new **CancerGuard** is a single-draw blood test that analyzes multiple biomarker classes to flag signals from **50+ cancers**. It’s a **\$689** U.S. **lab-developed test** meant to **complement** existing screenings—not replace them. ([Exact Sciences][1])
[1]: https://www.exactsciences.com/newsroom/press-releases/exact-sciences-launches-cancerguard-first-of-its-kind-multi-cancer-early-detection-blood-test “Exact Sciences Launches Cancerguard, First-of-Its-Kind Multi-Cancer Early Detection Blood Test | Exact Sciences”
Two fresh bites on longevity: one thread champions a “longevity diet” as a legit way to extend life, the other debates whether stacking lots of hacks beats keeping it simple. Takeaway—focus on consistent, evidence-leaning basics before chasing synergy. Want a quick start? Use our **AI Prompt of the Month** to auto-build a one-page daily plan (movement, simple strength, sleep, meals) tailored to you.
– Harvard’s David Sinclair predicts rejuvenation trials by 2027. – Surge in off-label Rapamycin usage for lifespan extension. – AI reengineers nobel-winning proteins to reverse
Researchers have shown that boosting the brain’s energy-producing mitochondria can reverse memory and motor problems in mice with dementia-like symptoms. Using a tool called mitoDREADD-Gs, scientists proved for the first time that mitochondrial dysfunction is not just linked to but can directly cause neurodegeneration.
This is the first long-term, randomized controlled trial to show that vitamin D can protect telomere length. It suggests that a simple, inexpensive supplement may not just support bone health—but could also help preserve the integrity of our DNA and slow biological aging itself.
Kidney stones affect 12% of people and often recur, leading to repeated surgeries and months of discomfort. Current treatments are slow, painful, or invasive. This approach could offer faster pain relief, fewer surgeries and a safe option for patients who can’t tolerate oral meds
Keratin-based toothpaste offers the first potential solution to permanently repair tooth enamel that was previously considered irreversibly damaged.
